The aim of this section is to gain new insight into the pathogenesis of eye diseases and develop new treatment modalities. A specific focus is directed towards new imaging modalities in glaucoma, diabetic retinopathy, age-related macular degeneration, dry eye symptom, and drug delivery.
Current Projects
Functional Optical Coherence Tomography
Neurovascular Coupling in the Retina and Optic Nerve Head
Mechanisms of Ocular Blood Flow Autoregulation
Role of Supplements in the Treatment of Eye Disease
New Approaches for the characterization and the treatment of Dry Eye Symptom
Cooperations
Center of Medical Physics and Biomedical Engineering, MUW
Department of Ophthalmology, MUW
Department of Ophthalmology and Vision Science, University of Toronto, Canada
Devers Eye Institute, Portland, Oregon, USA
Key Publications
Boltz A, Luksch A, Wimpissinger B, Maar N, Weigert G, Frantal S, Brannath W, Garhofer G, Ergun E, Stur M, Schmetterer L. Choroidal blood flow and progression of age-related macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 in press
Pemp B, Polska E, Karl K, Lasta M, Minichmayr A, Garhofer G, Wolzt M, Schmetterer L. Effects of antioxidants (AREDS medication) on ocular blood flow and endothelial function in an endotoxin-induced model of oxidative stress in humans. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):2-6.
Pemp B, Weigert G, Karl K, Petzl U, Wolzt M, Schmetterer L, Garhofer G. Correlation of flicker-induced and flow-mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers. Diabetes Care. 2009 Aug;32(8):1536-41.
Werkmeister RM, Dragostinoff N, Pircher M, Götzinger E, Hitzenberger CK, Leitgeb RA, Schmetterer L. Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels. Opt Lett. 2008 Dec 15;33(24):2967-9.
Resch H, Karl K, Weigert G, Wolzt M, Hommer A, Schmetterer L, Garhöfer G. Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):358-63.
Resch H, Garhofer G, Fuchsjäger-Mayrl G, Hommer A, Schmetterer L. Endothelial dysfunction in glaucoma. Acta Ophthalmol. 2009 Feb;87(1):4-12.
Hommer A, Fuchsjäger-Mayrl G, Resch H, Vass C, Garhofer G, Schmetterer L. Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4046-50.
Polska E, Simader C, Weigert G, Doelemeyer A, Kolodjaschna J, Scharmann O, Schmetterer L. Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure. Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3768-74.
