What we offer
beyond the usual phase I-IV capabilities: A wide array of special innovative techniques.
Cardiovascular Clinical Medicine
| Clinical Parameter | Method applied Systemic hemodynamics |
| Cardiac performance (Cardiac output, systolic function) | Impedance cardiography Echocardiography Systolic time intervals |
| Cardiac electrophysiology | Signal averaging ECG Holter ECG RR-Variability |
| Systemic blood pressure | Systemic blood pressure (Non-) invasive measurement 48 h ambulant blood pressure Pulse oxymetry |
| Skin and muscle blood flow | Laser Doppler flowmeter |
| Renal blood flow (RBF) Renal sodium excretion Glomerular filtration rate (GFR) Hepatic blood flow Forearm blood flow | PAH-Clearance Lithium-Clearance Inulin-Clearance ICG-Clearance, Ultrasound doppler Plethysmography |
| Venous responsiveness | Hand vein compliance technique Photoplethysmography |
| Conduit & resistence vessel blood flow | Forearm plethysmography High-resolution ultrasound brachial artery |
| Analyses: Endogenous nitric oxide inhibitors (ADMA, SDMA), andrenochrome metabolites | HPLC |
Clinical Pharmacokinetics / Pharmacogenetics and Imaging
| Clinical Parameter | |
| Phase I-IV studies Interstitial drug concentrations in skeletal muscle, subcutaneous adipose tissue, skin, solid tumors, brain, lung | Microdialysis |
| Transdermal bioequivalence | Microdialysis combined 2 D ultrasound Repeat skin biopsies Skin blister techniques serial skin biopsies |
| Gamma Scintigraphy: Activated samarium labeling, Tc99 labeling Mass balance studies | Activated samarium labeling, Tc99 labeling |
| Tissue drug concentrations | Magnetic Resonance Spectroscopy Micro PET |
Preclinical studies
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Hematology & Immunology
| Clinical Parameter First in human trials & biologicals | Method applied Biosimilarity trials and first in human trials with cytokines, chemokines, hematopoietic growth factors (such as filgrastim), antibodies (such as rituximab) |
| Anti-adhesive and anti-coagulant strategies in systemic inflammation | Endotoxemia in man (iv. infusion of Reference Standard E. Coli endotoxin) Endotoxin instillation into lung ssegments |
| Selective depletion of blood cells Biocompatibility testing Systemic inflammation and leukocyte emmigration | Extracorporal circulation Platelet-, Leucopheresis Hemodialysis, Extracorporeal membrane oxygenation, Left ventricular assist devices Cardiopulmonary bypass in patients undergoing cardiac surgery |
Method applied | |
| In vivo testing of anticoagulant drugs Thrombopoiesis and platelet turnover Platelet function Platelet receptor polymorphism Platelet receptor density Platelet function | Shed blood technique |
Ophthalmo-Pharmacology
| Clinical Parameter | Method applied |
| Retinal blood flow | Laser Doppler velocimetry |
| Choroidal and optic disk blood flow | Laser Doppler flowmetry |
| Optic disk and retinal blood flow | Scanning laser Doppler flowmetry (HRF) |
| Pulsatile ocular blood flow | Laser interferometric measurements of fundus pulsations |
Pulsatile ocular blood flow | Pneumotonometry |
| Retinal blood flow | Blue field and entoptic techniques |
| Flow velocities in extraocular vessels | Color Doppler imaging |
Biopharmaceutical and Chemical Analyses
| Development of new analytical methods and their application to samples from university and industry |
| Determination of antibiotics (Levofloxacin, Ciprofloxacin, Piperacillin, Cefazolin, Cefuroxime, Cefpirome, Fosfomycin) in plasma and tissue dialysates |
| Determination of modified amino acids (L-NMMA, Dimethylarginines) in plasma |
| Preparation of fused-silica capillary columns coated with low-bleed stationary phases for gas chromatography |
Determination of clopidogrel active metabolite and aspirin in plasma |
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